This article proposes a theoretical reflection on the experience of Multifamily Groups (GMF), developed from the framework of Integrative Psychoanalysis elaborated by Eduardo Mandelbaum. The model has its origins in the tradition of Maxwell Jones' therapeutic communities and in the first experiences at the Borda Psychiatric Hospital in Buenos Aires. Over time, it has been configured as a clinical device capable of articulating psychoanalysis with contributions from other psychotherapeutic currents, privileging a complex and non-reductionist view that links biology, conflict and history through words and group exchange.